Olanzapine (Common Indian Brands: Oliza, Oleanz, Zypine)

Introduction
Olanzapine is an antipsychotic medication frequently used to treat mental health conditions like schizophrenia and bipolar disorder. It belongs to the class of atypical antipsychotics and works by modulating the activity of certain neurotransmitters in the brain, such as dopamine and serotonin. Olanzapine helps reduce symptoms like hallucinations, delusions, and mood swings, enabling patients to manage their condition effectively.

Purpose of the Medication
Used to Treat:

Schizophrenia
Bipolar Disorder (acute mania or mixed episodes)
Adjunctive treatment for treatment-resistant depression (in combination with fluoxetine)
How It Works:

Blocks dopamine D2 and serotonin 5-HT2A receptors, helping to stabilize mood, reduce psychotic symptoms, and improve overall emotional functioning.
Key Information
How to Take It:

Common starting dose:
Schizophrenia: 5–10 mg once daily.
Bipolar Mania: 10–15 mg once daily.
Maximum dose: 20 mg/day (based on your doctor’s recommendation).
Take at the same time each day, with or without food.
Swallow the tablet whole; do not crush or chew.
Orally disintegrating tablets are available; allow them to dissolve in the mouth.
Common Side Effects:

Weight gain
Drowsiness or sedation
Increased appetite
Dry mouth
Constipation
Dizziness
Serious Side Effects:

Contact your doctor immediately if you experience:
Severe muscle stiffness, high fever, or confusion (Neuroleptic Malignant Syndrome).
High blood sugar symptoms (e.g., excessive thirst, frequent urination).
Sudden uncontrollable movements or tremors.
Symptoms of a serious allergic reaction (e.g., rash, swelling, difficulty breathing).
Precautions
Before Taking: Inform your doctor if you have:

A history of diabetes or risk factors for high blood sugar.
Liver or kidney problems.
A history of seizures or epilepsy.
A cardiovascular condition or risk factors like high blood pressure.
Pregnancy, are planning to conceive, or are breastfeeding.
Any allergies or if you use Ayurvedic, herbal, or homeopathic supplements.
While Taking:

Avoid alcohol, as it may increase sedation or dizziness.
Be cautious when driving or operating machinery, as olanzapine can impair your alertness.
Monitor weight and blood sugar levels regularly, especially if you have diabetes or are at risk for it.
Storage
Store in a cool, dry place away from sunlight and moisture.
Keep out of reach of children and pets.
Missed Dose
Take it as soon as you remember unless it’s close to your next scheduled dose.
Do not take a double dose to make up for a missed one.
Interactions
Medicines to Avoid Without Doctor’s Advice:

Other antipsychotics or antidepressants.
Sedatives or sleeping pills, as they may increase drowsiness.
Medications that can prolong the QT interval (e.g., certain heart medications).
Herbal supplements like St. John’s Wort.
Always inform your doctor about all medications, including traditional and alternative therapies.

Emergency Contact
Overdose Symptoms: Severe drowsiness, confusion, agitation, seizures, or irregular heartbeat.

Contact the Poison Information Centre, AIIMS New Delhi, at 011-26589391 or visit the nearest emergency room immediately.
Additional Notes
Brands Available in India:

Oliza (Intas): 5 mg, 10 mg, 20 mg tablets.

Oleanz (Sun Pharma): 2.5 mg, 5 mg, 10 mg, 20 mg tablets.

Zypine (Lupin): 2.5 mg, 5 mg, 10 mg tablets.

It may take 1–2 weeks for initial symptom relief and 4–6 weeks for full effects.

Avoid abrupt discontinuation to prevent withdrawal symptoms such as restlessness or agitation.

Regular follow-ups with your doctor are crucial to monitor weight, blood sugar, and side effects, and to adjust the dose as necessary.