Sleep disturbances and stress often travel together, each feeding into the other. For many, addressing just one piece of the puzzle—like circadian rhythm or anxiety—doesn’t go far enough. This is where Melora, a formulation that combines melatonin with Lactium® (α-casozepine), steps in.

What Is Melora?

Melora is designed as a dual-action nutraceutical:

• Melatonin → The body’s natural “darkness hormone,” signaling it’s time to sleep. It’s most effective for sleep-onset insomnia, jet lag, and circadian rhythm disorders.

• Lactium® (α-casozepine) → A bioactive peptide derived from milk protein casein. Early research suggests it binds weakly to GABA-A receptors, the same calming pathway targeted by benzodiazepines, though in a gentler fashion. It has been studied for reducing stress and lowering cortisol levels.

Together, the aim is to help the body both switch off and calm down, especially in people whose insomnia is fueled by stress or anxious rumination.

The Science So Far

• Melatonin has a robust evidence base. It can shorten sleep latency and improve sleep quality in circadian-related disturbances.

• Lactium® is supported by smaller RCTs showing reductions in stress perception and cortisol. Though less well-researched than melatonin, its safety profile is favorable.

• The combination hasn’t yet been studied in large clinical trials as a fixed formulation. Current evidence is extrapolated: melatonin for circadian alignment, Lactium for stress modulation.

Who Might Benefit?

• Professionals facing high stress with difficulty winding down at night.

• Students experiencing exam anxiety with sleep-onset issues.

• Older adults where mild anxiety complicates insomnia.

Important note: Melora isn’t a replacement for professional evaluation in cases of chronic insomnia, depression, or anxiety disorders. It’s positioned more as a supportive aid.

Practical Considerations

• Dosing varies by brand; typical melatonin doses range from 1–5 mg, while Lactium is studied at ~150–300 mg/day. Always check labels and consult a clinician.

• Side effects are mild: melatonin can sometimes cause morning grogginess or vivid dreams; Lactium is usually well-tolerated.

• Safety: Avoid if allergic to milk proteins, pregnant, or breastfeeding, unless medically advised.

The Bottom Line

Melora’s concept is appealing: combining the well-documented circadian signal of melatonin with the gentle calming potential of Lactium. While more direct studies are needed, it offers a promising, natural-leaning option for stress-related sleep problems.

About Me

I’m Dr. Srinivas Rajkumar T, Consultant Psychiatrist, researcher, and writer with a keen interest in psychopharmacology and practical approaches to mental health. I work at the intersection of clinical practice, digital health, and education, with a focus on strategies that help people live healthier, more balanced lives.

📞 For consultations, contact: 8595155808